Application area
- health care
- drug discovery
- pharmacy
- environmental monitoring
- forensic science
- homeland security
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Technical performance
- The patented design of the device is a combination of a multifunctional sample introduction and ionization system, drift tube ion mobility spectrometer and sector TOF mass spectrometer with orthogonal acceleration
- Multifunction sample introduction and ionization system works with both integrated ion sources and external available engineering solutions. Integrated ionization platform allows to use electrospray (ESI), atmosphere pressure chemical ionization (APCI), atmosphere pressure photoionization (APPI)
- The high-resolution ion mobility spectrometer provides maximum selectivity compared to existing commercial instruments
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Detection limits obtained for some illicit drugs
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Compound
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Detection limit
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relative, M
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absolute, g
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Methylone
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3*10-7
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7*10-10
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4-MEC
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1.5*10-7
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4*10-10
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3,4-MDPV
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4*10-8
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1.5*10-10
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JWH-210
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4*10-7
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1.7*10-9
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JWH-250
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2.3*10-7
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7*10-10
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JWH-203
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3*10-7
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1.2*10-9
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Cocaine
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4*10-9
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1.4*10-11
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[A.A. Sysoev, S.S. Poteshin, D.M. Chernyshev, A.V. Karpov, Y.B. Tuzkov, V.V. Kyzmin, A.A. Sysoev, Analysis of new synthetic drugs by ion mobility time-of-flight mass spectrometry, European Journal of Mass Spectrometry, 2014, 20 (2), 185-192]
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Main advantages over conventional approaches
- The method allows to reach better sensivity than approaches based on orthogonal acceleration reflectron TOF analyzers
- This method allows to analyze gases and liquids much faster than liquid chromatography/mass spectrometry.
Mass-selective mobility distribution derived from IMS/MS data obtained for a mixture of tetrapropylammonium iodide, tetrapentylammonium iodide, and tetraoctylammonium bromide showing mobility resolving power R ranging in 70-120.
